List of Publications

2022

Lee BJ et al. (2022) L-type Ca2+ channels mediate regulation of glutamate release by subthreshold potential changes. PNAS (accepted)

Kwon J et al. (2022/12) Rewiring of prelimbic inputs to nucleus accumbens core underlies cocaine-induced behavioral sensitization. Biological Psychiatry. (in press) doi: 10.1016/j.biopsych.2022.12.024

Kim HH et al. (2022/12) Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse. Exp Neurobiol. 31(6):361-375. doi: 10.5607/en22028.

Eom K, Lee HR et al. (2022/03) Gradual decorrelation of CA3 ensembles associated with contextual discrimination learning is impaired by Kv1.2 insufficiency. Hippocampus. 32(3): 193-216. doi: 10.1002/hipo.23400

Lee BJ et al. (2022) Voltage-gated calcium channels contribute to spontaneous glutamate release directly via nanodomain coupling or indirectly via calmodulin Progress in Neurobiology 208: 102182.

2021

Yang CH et al. (2021) Postnatal maturation of glutamate clearance and release kinetics at the rat and mouse calyx of Held synapses. Synapse 75:e22215.

Yang CH et al. (2021) Inter‐spike mitochondrial Ca2+ release enhances high frequency synaptic transmission. The Journal of Physiology 599(5): 1567-1594.

Kim KR et al. (2021) Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation. Molecular brain, 14(1): 14-1.

2020

Song YH et al. (2020) Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1. Science Advances, 6(17) eaaz0517.

Kim KR et al. (2020) Kv4.1, a key ion channel for low frequency firing of dentate granule cells, is crucial for pattern separation. Journal of Neuroscience, 40(11): 2200-2214.

Yoon JY et al. (2020) Disparities in short-term depression among prefrontal cortex synapses sustain persistent activity in a balanced network. Cerebral Cortex 30(1): 113-134.

2019

Eom K, Hyun JH, Lee D, Kim S, Jeong HJ, Kang JS, Ho WK, Lee SH. (2019). Intracellular Zn2+ signaling facilitates mossy fiber input-induced heterosynaptic potentiation of direct cortical inputs in hippocampal CA3 pyramidal cells. J Neurosci. 39(20):3812-3831. doi: 10.1523/JNEUROSCI.2130-18.2019

Kim HH, Park JM, Lee SH, Ho WK. (2019). Association of mGluR-dependent LTD of excitatory synapses with endocannabinoid-dependent LTD of inhibitory synapses leads to EPSP to spike potentiation in CA1 pyramidal neurons. J Neurosci. 39(2):224.

2018

Yu W, Sohn JW, Kwon J, Lee SH, Kim S, Ho WK. (2018). Enhancement of dendritic persistent Na+ currents by mGluR5 leads to an advancement of spike timing with an increase in temporal precision. Mol Brain. 11(1):67.

Yu W, Kwon J, Sohn JW, Lee SH, Kim S, Ho WK. (2018). mGluR5-dependent modulation of dendritic excitability in CA1 pyramidal neurons mediated by enhancement of persistent Na+ currents. J Physiol. doi: 10.1113/JP275999. PMID: 29870060.

Kim S, Kim Y, Lee SH, Ho WK. (2018). Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse. eLife. 7. pii: e35269. doi: 10.7554/eLife.35269. PMID: 29578411.

Park D, Lee U, Cho E, Zhao H, Kim JA, Lee BJ, Regan P, Ho WK, Cho K, Chang S. (2018). Impairment of Release Site Clearance within the Active Zone by Reduced SCAMP5 Expression Causes Short-Term Depression of Synaptic Release. Cell Rep. 22(12):3339-3350. doi: 10.1016/j.celrep.2018.02.088. PMID: 29562188.

Han YE, Chun JN, Kwon MJ, Ji YS, Jeong MH, Kim HH, Park SH, Rah JC, Kang JS, Lee SH, Ho WK. (2018). Endocytosis of KATP Channels Drives Glucose-Stimulated Excitation of Pancreatic β Cells. Cell Rep. 22(2):471-481. doi: 10.1016/j.celrep.2017.12.049. PMID: 29320741.

2016

Kim HJ, Jeong MH, Kim KR, Jung CY, Lee SY, Kim H, Koh J, Vuong TA, Jung S, Yang H, Park SK, Choi D, Kim SH, Kang K, Sohn JW, Park JM, Jeon D, Koo SH, Ho WK, Kang JS, Kim ST, Cho H. (2016). Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression. eLife. 5. pii: e17159. doi: 10.7554/eLife.17159.

2015

Lee KH, Lee H, Yang CH, Ko JS, Park CH, Woo RS, Kim JY, Sun W, Kim JH, Ho WK, Lee SH. (2015). Bidirectional signaling of neuregulin-2 mediates formation of GABAergic synapses and maturation of glutamatergic synapses in newborn granule cells of postnatal hippocampus. J Neurosci. 35(50):16479-93.

Han YE, Ryu SY, Park SH, Lee KH, Lee SH, Ho WK. (2015). Ca(2+) clearance by plasmalemmal NCLX, Li(+)-permeable Na(+)/Ca(2+) exchanger, is required for the sustained exocytosis in rat insulinoma INS-1 cells. Pflugers Arch. 467(12):2461-72. doi: 10.1007/s00424-015-1715-3.

Han YE, Lim A, Park SH, Chang S, Lee SH, Ho WK. (2015). Rac-mediated actin remodeling and myosin II are involved in KATP channel trafficking in pancreatic β-cells. Exp Mol Med. 47:e190. doi: 10.1038/emm.2015.72. PMID: 26471000.

Hyun JH, Eom K, Lee KH, Bae JY, Bae YC, Kim MH, Kim S, Ho WK, Lee SH. (2015). Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells. J Physiol. 593(16):3617-43. doi: 10.1113/JP270372. PMID: 26047212

Kim HH, Lee KH, Lee D, Han YE, Lee SH, Sohn JW, Ho WK. (2015). Costimulation of AMPA and metabotropic glutamate receptors underlies phospholipase C activation by glutamate in hippocampus. J Neurosci. 35(16):6401-12. doi: 10.1523/JNEUROSCI.4208-14.2015.

Kim H, Yang I, Ryu SY, Won DH, Giri AG, Wang W, Choi H, Chin J, Hahn D, Kim E, Han C, Lee J, Nam SJ, Ho WK, Kang H. (2015). Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015. J Nat Prod. 78(3):363-7. doi: 10.1021/np5007586. PMID: 25689430

2014

Moon S, Han D, Kim Y, Jin J, Ho WK, Kim Y. (2014). Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Sci Rep. 4:4376. doi: 10.1038/srep04376.

2013

Hyun JH, Eom KS, Lee KH, Ho WK, Lee SH. (2013). Activity-dependent downregulation of D-type K+ channel subunit Kv1.2 in rat hippocampal CA3 pyramidal neurons. J Physiol. 591(Pt 22):5525-40. PMID: 23981714.

Lee JS, Ho WK, Neher E, Lee SH. (2013). Superpriming of synaptic vesicles after their recruitment to the readily releasable pool. Proc Natl Acad Sci U S A. 110(37): 15079-15084. PMID: 23980146.

Park SH, Ryu SY, Yu WJ, Han YE, Ji YS, Oh K, Sohn JW, Lim A, Jeon JP, Lee H, Lee KH, Lee SH, Berggren PO, Jeon JH, Ho WK. (2013). Leptin promotes KATP channel trafficking by AMPK signaling in pancreatic β-cells. Proc Natl Acad Sci U S A. 110(31):12673-8. doi: 10.1073/pnas.1216351110.

Lee JS, Kim MH, Ho WK, Lee SH. (2013). Developmental upregulation of presynaptic NCKX underlies the decrease of mitochondria-dependent post-tetanic potentiation at calyx of Held synapses. J. Neurophysiol. 109:1724-1734. PMID: 23282327.

Lee KH, Ho WK, Lee SH. (2013). Endocytosis of somatodendritic NCKX2 is regulated by Src family kinase-dependent tyrosine phosphorylation. Front Cell Neurosci. 7:14. doi:10.3389/fncel.2013.00014. PMID: 23431067.

Park SH, Ho WK, Jeon JH. (2013). AMPK regulates K(ATP) channel trafficking via PTEN inhibition in leptin-treated pancreatic β-cells. Biochem Biophys Res Commun. 440(4):539-44. doi: 10.1016/j.bbrc.2013.09.099. PMID: 24103758.

2012

Lee H, Lee D, Park C-H, Ho WK, Lee SH. (2012). GABA mediates the network activity-dependent facilitation of axonal outgrowth from the newborn granule cells in the early postnatal rat hippocampus. Eur J Neurosci. 36(6): 2743-2752.

Lee SH, Kim KR, Ryu SY, Hong HS, Mook-Jung I, Lee SH*, Ho WK*. (2012). Impaired short-term plasticity in mossy fiber synapses caused by mitochondrial dysfunction of dentate granule cells is the earliest synaptic deficit in a mouse model of Alzheimer’s disease. J Neurosci. 32(17): 5953–5963.

Lee JS, Ho WK, Lee SH. (2012). Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool. Proc Natl Acad Sci U S A, 109(13): E765-E774.

Lee KH, Lee JS, Lee DY, Seog DH, Lytton J, Ho WK, Lee SH. (2012). KIF21A-mediated axonal transport and selective endocytosis underlie the polarized targeting of NCKX2. J Neurosci, 32(12): 4102-4117.

Cho HJ, Lee HJ, Youn SW, Koh SJ, Won JY, Chung YJ, Cho HJ, Yoon CH, Lee SW, Lee EJ, Kwon YW, Lee HY, Lee SH, Ho WK, Park YB, Kim HS. (2012). Secondary sphere formation enhances the functionality of cardiac progenitor cells. Mol Ther. 20(9):1750-66. doi: 10.1038/mt.2012.109. PMID: 22713697.

Han D, Moon S, Kim Y, Ho WK, Kim K, Kang Y, Jun H, Kim Y. (2012). Comprehensive phosphoproteome analysis of INS-1 pancreatic β-cells using various digestion strategies coupled with liquid chromatography-tandem mass spectrometry. J Proteome Res. 11(4):2206-23. doi: 10.1021/pr200990b. PMID: 22276854.

2011

Sohn JW, Yu WJ, Lee DY, Shin HS, Lee SH, Ho WK. (2011). Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons. PLoS One. 6(10): e26625.

Rhee YH, Ko JY, Chang MY, Yi SH, Kim D, Kim CH, Shim JW, Jo AY, Kim BW, Lee H, Lee SH, Suh W, Park CH, Koh HC, Lee YS, Lanza R, Kim KS, Lee SH. (2011). Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest. 121(6): 2326-35. doi: 10.1172/JCI45794.

Song YH, Choi E, Park SH, Lee SH, Cho H, Ho WK, Ryu SY. (2011). Sustained CaMKII activity mediates transient oxidative stress-induced long-term facilitation of L-type Ca(2+) current in cardiomyocytes. Free Radic Biol Med. 51(9):1708-16. PMID: 21854842.

He XB, Yi SH, Rhee YH, Kim H, Han YM, Lee SH, Lee H, Park CH, Lee YS, Richardson E, Kim BW, Lee SH. (2011). Prolonged Membrane Depolarization Enhances Midbrain Dopamine Neuron Differentiation via Epigenetic Histone Modifications. Stem Cells. 29(11): 1861-73. doi: 10.1002/stem.739. PMID:21922608.

2010

Lee JS, Ho WK, Lee SH. (2010). Post-tetanic increase in the fast-releasing synaptic vesicle pool at the expense of the slowly releasing pool. J Gen Physiol. 136(3):259-72.

Song YH, Cho H, Ryu SY, Yoon JY, Park SH, Noh CI, Lee SH, Ho WK. (2010). L-type Ca2+ channel facilitation mediated by H2O2-induced activation of CaMKII in rat ventricular myocytes. J Mol Cell Cardiol. 2010-4, 48(4):773-80.

Lee TH, Song SH, Kim KL, Yi JY, Shin GH, Kim JY, Kim J, Han YM, Lee SH, Lee SH, Shim SH, Suh W. (2010). Functional recapitulation of smooth muscle cells via induced pluripotent stem cells from human aortic smooth muscle cells. Circ Res. 106(1):120-128.

Cui S, Ho WK, Kim ST, Cho H. (2010). Agonist-induced localization of Gq-coupled receptors and G protein-gated inwardly rectifying K+ (GIRK) channels to caveolae determines receptor specificity of phosphatidylinositol 4,5-bisphosphate signaling. J Biol Chem. 85(53):41732-9. doi: 10.1074/jbc.M110.153312. PMID: 21041306.

Lee SY, Choi HK, Kim ST, Chung S, Park MK, Cho JH, Ho WK, Cho H. (2010). Cholesterol inhibits M-type K+ channels via protein kinase C-dependent phosphorylation in sympathetic neurons. J Biol Chem. 285(14):10939-50. doi: 10.1074/jbc.M109.048868. PMID: 20123983.

2009

Lee SH, Ho WK, Lee SH. (2009). Characterization of somatic Ca2+ clearance mechanisms in young and mature hippocampal granule cells. Cell Calcium. 45:465-473.

Lim A, Park SH, Sohn JW, Jeon JH, Lee SH, Ho WK. (2009). Glucose deprivation regulates KATP channel trafficking via AMPK in pancreatic b-cells. Diabetes. 58:2813-9.

Yoon JY, Ho WK, Kim ST, Cho H. (2009). Constitutive CaMKII activity regulates Na+ channel in rat ventricular myocytes. J Mol Cell Cardiol. 47(4):475-84. doi: 10.1016/j.yjmcc.2009.06.020. PMID: 19591836.

Kim JS, Zheng H, Kim SJ, Park JW, Park KS, Ho WK, Chun YS. (2009). Role of aryl hydrocarbon receptor nuclear translocator in KATP channel-mediated insulin secretion in INS-1 insulinoma cells. Biochem Biophys Res Commun. 379(4):1048-53. doi: 10.1016/j.bbrc.2009.01.004. PMID: 19141293.

2008

Jang J, Ku SY, Kim JE, Choi K, Kim YY, Kim HS, Oh SK, Lee EJ, Cho HJ, Song YH, Lee SH, Lee SH, Suh CS, Kim SH, Moon SY, Choi YM. (2008). Notch inhibition promotes human embryonic stem cell-derived cardiac mesoderm differentiation. Stem Cells. 26(11):2782–2790.

Lee JS, Kim MH, Ho WK, Lee SH. (2008). Presynaptic release probability and the readily-releasable pool size are regulated by two independent mechanisms during post-tetanic potentiation at the calyx of Held synapse. J Neurosci. 28(32): 7945-7953.

Chang SA, Lee EJ, Kang HJ, Zhang SY, Kim JH, Li L, Youn SW, Lee CS, Kim KH, Won JY, Sohn JW, Park KW, Cho HJ, Yang SE, Oh WI, Yang YS, Ho WK, Park YB, Kim HS. (2008). Impact of myocardial infarct proteins and oscillating pressure on the differentiation of mesenchymal stem cells: effect of acute myocardial infarction on stem cell differentiation. Stem Cells. 26(7):1901-12. doi: 10.1634/stemcells.2007-0708. PMID: 18403756.

2007

Lee DY, Lee KH, Ho WK, Lee SH. (2007). Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. J Neurosci. 27(50):13603-13.

Sohn JW, Lim A, Lee SH, Ho WK. (2007). Decrease in PIP2–channel interactions is the final common mechanism involved in PKC- and arachidonic acidmediated inhibitions of GABAB-activated K+ current. J Physiol. 582.3: 1037–1046.

Joo J-Y, Kim B-W, Lee J-S, Park J-Y, Kim S, Yun Y-J, S-H Lee, S-H Lee, Rhim H, Son H. (2007). Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells. J Cell Sci. 120:1358-1370.

Lee SH, Park KH, Ho WK, Lee SH. (2007). Postnatal developmental changes in Ca2+ homeostasis in supraoptic magnocellular neurons. Cell Calcium. 41:441-450.

Sohn JW, Lee D, Cho H, Shin HS, Lim W, Lee SH, Ho WK. (2007). Receptor-specific inhibition of GABAB-activated K+ currents by muscarinic and metabotropic glutamate receptors in immature rat hippocampus. J Physiol. 580.2: 411-422.

Lee SH, Kim MH, Lee JY, Lee SH, Lee D, Park KH, Ho WK. (2007). Na+/Ca2+ exchange and Ca2+ homeostasis in axon terminals of Mammalian central neurons. Ann N Y Acad Sci. 1099:396-412.

Lee JY, Ho WK, Lee SH. (2007). Ionic Selectivity of NCKX2, NCKX3, and NCKX4 for Monovalent Cations at K+-Binding Site. Ann N Y Acad Sci. 1099:166-70.

Bae YM, Kim A, Lee YJ, Lim W, Noh YH, Kim EJ, Kim J, Kim TK, Park SW, Kim B, Cho SI, Kim DK, Ho WK. (2007). Enhancement of receptor-operated cation current and TRPC6 expression in arterial smooth muscle cells of deoxycorticosterone acetate-salt hypertensive rats. J Hypertens. 25(4):809-17. PMID: 17351373.

2006

Lee JY, Visser F, Lee JS, Lee KH, Soh JW, Ho WK, Lytton J, Lee SH. (2006). Protein Kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 Cells. J Biol Chem. 281(51):39205-39216.

Fish JM, Welchons DR , Kim YS, Lee SH, Ho, WK, Antzelevitch C. (2006). Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 113: 1393-1400.

Cho H, Kim YA, Ho WK. (2006). Phosphate number and acyl chain length determine the subcellular location and lateral mobility of phosphoinositides. Mol Cells. 22(1):97-103. PMID: 16951556.

Jo SH, Choi SY, Yun JH, Koh YS, Ho WK, Lee CO. (2006). Chemical modification of the human ether-a-go-go-related gene (HERG) K+ current by the amino-group reagent trinitrobenzene sulfonic acid. Arch Pharm Res. 29(4):310-7. PMID: 16681037

2005

Ryu SY, Lee SH, Ho WK. (2005). Generation of metabolic oscillation by mitoKATP and ATP synthase during simulated ischemia in ventricular myocytes. J Mol Cell Cardiol. 39:874-881.

Cho H, Kim YA, Yoon JY, Lee D, Kim JH, Lee SH, Ho WK. (2005). Low mobility of phosphatidylinositol 4,5-bisphosphate underlies receptor specificity of Gq-mediated ion channel regulation in atrial myocytes. Proc Natl Acad Sci U S A. 102(42):15241–15246.

Kim MH, Korogod N, Schneggenburger R, Ho WK, Lee SH. (2005). Interplay between Na+/Ca2+ exchangers and mitochondria in Ca2+-clearance at the calyx of Held. J Neurosci. 25 (26) 6057-6065.

Cho H, Lee D, Lee SH, Ho WK. (2005). Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K+ channels in a receptor-specific manner. Proc Natl Acad Sci U S A. 102(12):4643-8.

2004

Yoon JY, Ahn SH, Oh H, Kim YS, Ryu SY, Ho WK, Lee SH. (2004). A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Brit J Pharmacol. 143: 765-773.

Lee SH, Sohn JW, Ahn SC, Park WS, Ho WK. (2004). Li+ enhances GABAergic inputs to granule cells in the rat hippocampal dentate gyrus. Neuropharmacology. 46(5): 638-646.

Han J, Bae JH, Kim SY, Lee HY, Jang BC, Lee IK, Cho CH, Lim JG, Suh SI, Kwon TK, Park JW, Ryu SY, Ho WK, Earm YE, Song DK. (2004). Taurine increases glucose sensitivity of UCP2-overexpressing beta-cells by ameliorating mitochondrial metabolism. Am J Physiol Endocrinol Metab. 287(5):E1008-18. PMID: 15265758.

Lee SY, Choi SY, Youm JB, Ho WK, Earm YE, Lee CO, Jo SH. (2004). Block of HERG human K(+) channel and IKr of guinea pig cardiomyocytes by chlorpromazine. J Cardiovasc Pharmacol. 43(5):706-14. PMID: 15071359.

Kim A, Bae YM, Kim J, Kim B, Ho WK, Earm YE, Cho SI. (2004). Direct block by bisindolylmaleimide of the voltage-dependent K+ currents of rat mesenteric arterial smooth muscle. Eur J Pharmacol. 483(2-3):117-26. PMID: 14729098.

Youm JB, Earm YE, Ho WK. (2004). Modulation of HERG channel inactivation by external cations. Eur Biophys J. 33(4):360-9. PMID: 14586519

2003

Kim MH, Lee S, Park KH, Ho WK, Lee SH. (2003). Distribution of K+-dependent Na+/Ca2+ exchangers in the rat supraoptic magnocellular neuron is polarized to axon terminals. J Neurosci. 23(37): 11673–11680.

Lee SH, Lee EH, Ryu SY, Baek HJ, Lim HW, Ho WK. (2003). The role of K+ channels in frequency regulation of spontaneous action potentials in rat pituitary GH3 cells. Neuroendocrinology. 78(5): 260-269.

Park KS, Kim Y, Lee YH, Earm YE, Ho WK. (2003). Mechanosensitive cation channels in arterial smooth muscle cells are activated by diacylglycerol and inhibited by phospholipase C inhibitor. Circ Res. 93(6):557-64. PMID: 12946944

Piao L, Ho WK, Earm YE. (2003). Actin filaments regulate the stretch sensitivity of large-conductance, Ca2+-activated K+ channels in coronary artery smooth muscle cells. Pflugers Arch. 446(5):523-8. PMID: 12748862.

2002

Lee SH, Kim MH, Park KH, Earm YE, Ho WK. (2002). K+-dependent Na+/Ca2+ exchanger is a major Ca2+ clearance mechanism in axon terminals of rat neurohypophysis. J Neurosci. 22(16):6891-6899.

Ryu SY, Lee SH, Isenberg G, Ho WK, Earm YE. (2002). Monitoring of ANP secretion from single atrial myocytes using densitometry. Pflugers Arch. 444(4):568-577.

Bae YM, Kim KS, Ko E, Lee SH, Ho WK, Earm YE. (2002). Intracellular Mg2+ hyperpolarizes rabbit coronary artery smooth muscle cells by differential modulation of Ca2+i-dependent ion channels. Pflugers Arch. 444(4):523-531.

Park WS, Lee SH. (2002). Ca2+ influx is responsible for afterdepolarization in rat hippocampal dentate granule cells. Kor J Physiol Pharm. 6(3):143-147.

Cho H, Hwang JY, Kim D, Shin HS, Kim Y, Earm YE, Ho WK. (2002). Acetylcholine-induced phosphatidylinositol 4,5-bisphosphate depletion does not cause short-term desensitization of G protein-gated inwardly rectifying K+ current in mouse atrial myocytes. J Biol Chem. 277(31):27742-7. PMID: 12019267.

2001

Bae YM, Kim KS, Park JK, Ko E, Ryu SY, Baek HJ, Lee SH, Ho WK, Earm YE. (2001). Ca2+i-dependent membrane currents in vascular smooth muscle cells of the rabbit. Life Sciences. 69:2451-2466

Cho H, Nam GB, Lee SH, Earm YE, Ho WK. (2001). Phosphatidylinositol 4,5-bisphosphate is acting as a signal molecule in 1-adrenergic pathway via the modulation of acetylcholine-activated K+ channel in mouse atrial myocytes. J Biol Chem. 276(1):159-164.

1990 - 2000

Lee SH, Schwaller B, Neher E. Kinetics of Ca2+ binding to parvalbumin in bovine chromaffin cells: implications for [Ca2+] transients of neuronal dendrites. J Physiol. 525 Pt 2:419-32, 2000.

Lee SH, Rosenmund C, Schwaller B, Neher E. Differences in Ca2+ buffering properties between excitatory and inhibitory hippocampal neurons from the rat. J Physiol. 525 Pt 2:405-18, 2000.

Youm JB, Ho WK, Earm YE. Stretch-activated cation channels in rat atrial myocytes. Jap J Electrocardiology 20 (Supp 3):23-29, 2000

Youm JB, Ho WK, Earm YE. Permeability cahracteristics of the monovalent cations in atrial myocytes of the rat heart. Exp Physiol 85(2):143-150, 2000.

Jo SH, Youm JB, Lee CO, Earm YE, Ho WK. Blockade of HERG human cardiac K+ channel by the antidepressant drug amitriptyline. Br J Pharmacol 129:1474-1480, 2000

Song DK, Ahn YH, Bae JH, Park WK, Hong YS, Ho WK, Earm YE. Evidences of enhancement of malate-aspartate shuttle activity in beta cells of streptozotocin-induced NIDDM rats. Metabolism 49(1):92-96, 2000

Zhang YH, Youm JB, Sung HK, Lee SH, Ho WK, Earm YE. Stretch-activated and background non-selective cation channels in rat atrial myocytes. J Physiol 523(3):607-619, 2000

Song DK, Earn YE, Ho WK. Blockade of the delayed rectifier K+ current in rabbit sino-atrial node cells by external divalent cations. Pflügers Arch 438:147-153, 1999.

Jo SH, Youm JB, Kim IJ, Lee CO, Earm YE, Ho WK. Blockade of HERG channels expressed in Xenopus oocytes by external H+. Pflügers Arch 438:23-29, 1999.

Ho WK, Kim IJ, Lee CO, Youm JB, Earm YE. Blockade of human-eag channels expressed in Xenopus laevis oocytes by external divalent cations. Biophys J 76: 1959-1971, 1999.

Bae YM, Park MK, Lee SH, Ho WK, Earm YE. Contribution of Ca2+-activated K+ channels and non-selective cation channel to membrane potential of pulmonary arterial smooth muscle cells of the rabbit. J Physiol 514: 747-758, 1999.

Park MK, Kang TM, Uhm DY, Lee SJ, Lee SH, Ho WK, Earm YE. Differential contractile properties between intralobar and extralobar pulmonary arteries of the rabbit. J Smooth M Res 35(1):1-10, 1999.

Lee SH, Ho WK, Earm YE. Effect of intracellular Na+, Mg2+ and metabolites on Ca2+-activated K+ channels in pulmonary and ear arterial smooth muscle cells of the rabbit. Exp Physiol 83: 707-715, 1998.

Yoo S, Lee SH, Choi BH, Yeom JB, Ho WK, Earm YE. Dual effect of nitric oxide on the hyperpolarization-activated inward current (If) in sino-atrial node cells of the rabbit. J Mol Cell Cardiol 30: 2729-2738, 1998.

Ho WK, Kim IJ, Lee CO, Earm YE. Voltage-dependent blockade of HERG channels expressed in Xenopus oocytes by external Ca2+, Mg2+. J Physiol 507(3): 631-638, 1998.

Han J, Kim EY, Lee SH, Yoo S, Ho WK, Earm YE. Cyclic GMP facilitates calcium current via cGMP-dependent protein kinase in isolated rabbit ventricular myocytes. Pflugers Arch 435(3): 388-393, 1998.

Song DK, Choe BK, Bae JH, Park WK, Han IS, Ho WK, Earm YE. Brain-derived neurotrophic factor rapidly potentialtes synaptic transmission through NMDA, but suppresses it through non-NMDA receptors in rat hippocampal neuron. Brain Res 799:176-179, 1998.

Park MK, Bae YM, Lee SH, Ho WK, Earm YE. Modulation of voltage-dependent K+ channel by redox potential in pulmonary, ear arterial smooth muscle cells of the rabbit. Pflugers Arch 434: 764-771, 1997.

Kim E, Han J, Ho WK, Earm YE. Modulation of ATP-sensitive K+ channels in rabbit ventricular myocytes by adenosine A1 receptor activation. Am J Physiol: Heart, Cir Physiol, 41/number 1: H325-H333, 1997.

Han J, Kim E, Ho WK, Earm YE. Effects of volatile anesthetic isoflurance on ATP-sensitive K+ channels in rabbit ventricular myocytes. Bioch Biophy Res Comm 229:852-856, 1996.

Han J, Kim E, Ho WK, Earm YE. Blockade of the ATP-sensitive potassium channel by taurine in rabbit ventricular myocytes. J Mol Cell Cardiol 28:2043-2050, 1996.

Ho WK, Earm YE, Lee SH, Brown HF, Noble D. Voltage-, time-dependent block o fdelayed rectifier K+-current in rabbit sino-atrial node cells by external Ca2+, Mg2+. J Physiol 494:727-742, 1966.

Leem CH, Ho WK, Earm YE. The effect taurine on the activation osmolality of the osmosensitive curren in single ventricular myocytes of rabbits. Exp Physiol 81:189-202, 1996.

Han J, Kim E, Ho WK, Earm YE. Sulfhydryl redox modulates ATP-sensitive K channels in rabbit ventricular myocytes. Bioch Biophy Res Comm 219:900-903, 1996.

Park MK, Lee SH, WK Ho, Earm YE. Redox agents as a link between hypoxia, the responses of ionic channels in pulmonary vascular smooth muscle. Exp Physiol 80:835-842, 1995.

Park MK, Lee SK, Lee SJ, Ho WK, Earm YE. Differential modulation of Ca-activated K channel by intracellular redox in pulmonary, ear arterial smooth muscle cells of the rabbit. Pflugers Arch 430:308-314, 1995.

Ho WK, Noble D, Earm YE. Effects of external Ca, Mg ions on the K conductance in sinoatrial node cells of the rabbit. Heart & Vessels 9(Supp): 17-18, 1995.

Han J, Kim E, Ho WK, Earm YE. Modulation of ATP-sensitive potassium channels in rabbit ventricular myocytes by endogenous modulators. Heart & Vessels 9(Supp): 94-96, 1995.

Han J, Kim E, Ho WK, Earm YE. Blockade of ATP-sensitive potassium channels in rabbit ventricular myocytes by sulfhydryl oxidation. Heart & Vessels 9(Supp): 100-101, 1995.

Park MK, Lee SH, Lee SJ, Ho WK, Earm YE. Differential modulation of Ca-activated K channel by intracellular redox in pulmonary, ear arterial smooth muscle cells of the rabbit. Pflugers Arch 430:308-314, 1995.

Lee SH, Earm YE. Caffeine induces periodic oscillations of Ca(2+)-activated K+ current in pulmonary arterial smooth muscle cells. Pflugers Arch. 426(3-4):189-98, 1994.

Ho WK, Brown HF, Noble D. High selectivity of the if channel to Na+, K+ in rabbit isolated sinoatrial node cells. Pflugers Arch 426:68-74, 1994.

Earm YE, Ho WK, So IS. Effect of adriamycin on ionic currents in single cardiac myocytes of the rabbit. J Mol Cell Cardiol 26:163-172, 1994.

Han J, Leem CH, So IS, Kim E, Hong S, Ho WK, Sung H, Earm YE. Effect of thyroid hormone on the calcium current, isoprenaline-induced background current in rabbit ventricular myocytes. J Mol Cell Cardiol 26:925-935, 1994.

Ho WK, Brown HF, Noble D. Internal K ions modulate the action of external cations on hyperpolarization-activated inward current in rabbit isolated sinoatrial node cells. Pflugers Arch 424:308-314, 1993.

Ho WK, Earm YE. Voltage dependence, kinetics of Na-Ca exchange tail current in rabbit atrial myocytes. Ann N Y Acad Sci 465-467, 1991.

Noble D, Noble SJ, Bett GCL, Earm YE, Ho WK, So IS. The role of sodium-calcium exchange during the cardiac action potential. Ann N Y Acad Sci 334-353, 1991.

Earm YE, Ho WK, So IS. Effects of Ca2+-buffer concentration, stimulus interval on the voltage dependence, timecourse of calcium-release-dependent inward current in rabbit atrial myocytes. Proc R Soc Lond B 246:285-292, 1991.

Earm YE, Ho WK, So IS. Inward current generated by Na-Ca exchange during the action potential in single atrial cells of the rabbit. Proc R Soc Lond B 240:61-81,1990.