Synaptic and Network Dynamics in the Prefrontal Cortex
Persistent activity in the prefrontal cortex (PFC), recognized as the neural basis for working memory, is a combined outcome of the organization of excitatory and inhibitory populations and the synaptic dynamics within their connections. We consider the contribution of short-term synaptic plasticity (STP) at PFC synapses to persistent activity, in the context of a balanced network model.
Presynaptic Mechanisms of Short-Term Plasticity
Presynaptic terminals are the center of action for short-term plasticity (STP). Quantitative analysis at the Calyx of Held has allowed us to elucidate the calcium clearance mechanisms that render vesicles release-ready, in addition to dissecting two sequential steps of release, providing better understanding of the molecular mechanisms of neurotransmitter release and STP.
Synaptic Modulation of Neuronal Excitability in CA3
The CA3 is an integration point for dentate gyrus (DG) and cortical inputs, and involved with both pattern separation and pattern completion. Heterosynaptic interaction between mossy fiber (MF) and perforant path (PP) inputs may thus be of crucial importance for understanding how CA3 pyramidal cells resolve those two complementary cognitive tasks.
Alcoholism and grad school life
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